Fei Chen ( JNK ) - terminal Kinase 2 B ) and c - Jun NH κ B ( NF - κ Nuclear Factor - Reactive Oxygen Species ( ROS ) , Troublemakers between Updated

Nuclear factorB (NFB) and c-Jun NH2-terminal kinase (JNK) are activated simultaneously under a variety of stress conditions. They also share several common signaling pathways for their activation in response to cytokines or growth factors. Recent studies, however, demonstrated a new form of interplay between these two allies. Inhibition of NFB by ikk or rela gene deficiency sensitizes stress responses through enhanced or prolonged activation of JNK. Conversely, sustained activation of NFB inhibits cytokine-induced JNK activation. The mechanisms of how NFB and JNK become rivals for each other are under extensive debate.